Endocrine Abstracts

RET is a tyrosine-kinase receptor having a GPI-linked co-receptor or GFRα. Moreover, RET has four different ligands (GDNF, NTN, ART and PSP) with its respective co-receptor (GFRα-1,-2,-3 and 4). Pituitary cells are differentiated specialized secretory cells. Sommatotrophs are responsible for growth during infancy and puberty until achievement of the final adult height. Although genetic factors leading to somatotroph hypoplasia are well known, no much is known about t...